C.H. Jonathan Choi Research Group

By exploring how nanoparticles interact with the living system across the length scales of organs, tissues, cells, and organelles, we design novel bionanomaterials for treating diseases arisen from various biological locations in vivo.

Research >> Research Interest | Research Grants

(PI and Co-I represent principal investigator and co-investigator, respectively.)

On-going

Research Grants Council, Research Fellowship Scheme, RFS2324-4S01. Preclinical translation of spherical nucleic acid nanostructures for managing cardiovascular diseases. PI, HKD 5.16 million, 01/01/2024–31/12/2028.

Research Grants Council, General Research Fund. Bypassing the hurdles to effective intracellular delivery of nucleic acids via gold@polydopamine plasmonic nanoworms. PI, 2021–2024.

Innovation and Technology Fund, Midstream Research Project. A nanotechnology platform for profiling diabetes-related miRNA for precision medicine, Co-A (33% of the research project), 6/2021–11/2023.

Research Grant Council, General Research Fund. Systemic delivery of microRNA for reducing atherosclerosis via RNA-coated nanoparticles, PI, 2020-2023.

Completed

Research Grants Council, General Research Fund, 14300718. “Bio-nano” interactions between hydrocarbyl-terminated nanoparticles and the cell: Endocytosis, trafficking, and exocytosis. PI, HKD 0.34 million, 1/2019–12/2021.

National Natural Science Foundation of China (NSFC) / Research Grants Council (RGC) Joint Research Scheme. Development of efficient gene carriers based on self-assembled DNA nanostructures and understanding their interactions with the cell, Hong Kong PI, 2017-2020.

Research Grant Council, General Research Fund. A novel polydopamine@poly(adenylic acid) nanoparticle for crossing the blood-brain barrier and selectively targeting neurons in vivo, PI, 2016-2019.

Research Grant Council: Early Career Scheme Grant. Mechanistic investigations of the “bio-nano” interactions between anisotropic bionanomaterials and the living system, PI, 2014-2017.

The Chinese University of Hong Kong, Shun Hing Institute of Advanced Engineering. Mechanism for the transcytosis of targeted nanoparticles across the blood-brain barrier, PI, 2014-2016.

Croucher Foundation: Postdoctoral Research Fellowship. Metal-DNA nanoconjugates as contrast agents for dual tumor detection and treatment, PI, 2011-2013.