(* denotes corresponding author. † denotes equal contribution. Number of Web of Science citations > 6200; Number of Google Scholar citations > 8900)
Xiao Y†, Liang Z†, Shyngys M, Baekova A, Cheung S, Muljadi MB, Bai Q, Zeng L, Choi CHJ* . In vivo interactions of nucleic acid nanostructures with cells. Adv. Mater. , in press. DOI: 10.1002/adma.202314232. (Invited Review for the Special Issue on "The Chinese University of Hong Kong 60th Anniversary".) [Abstract & Full Text] Yang L, Choi CHJ* , Wang J*, Xia J*, Zhang L*, Ngai T*, Zi Y*, Huang Z*. Celebrating 60 years of The Chinese University of Hong Kong: Research highlights in nanoscience and nanotechnology. ACS Nano , 18 , 1, 4–13 (2024). [Abstract & Full Text] Liang Z†, He Y†, Ieong CSI, Choi CHJ* . Cell-nano interactions of polydopamine nanoparticles. Curr. Opin. Biotechnol. , 84 , 103013 (2023). (Invited Minireview for the Special Issue on “Nanobiotechnology 2024” .) [Abstract & Full Text] Chan CKW, Szeto CC, Lee LKC, Xiao Y, Yin B, Ding X, Lee TWY, Lau JYW*, Choi CHJ* . A sub-10 nm, folic acid-conjugated gold nanoparticle as self-therapeutic treatment of tubulointerstitial fibrosis. Proc. Natl. Acad. Sci. USA , 120 , 42, e2305662120 (2023). (This work received a silver medal from the 49th International Exhibition of Inventions Geneva (IEIG) and coverage by the Swiss newspaper La Liberté . See additional coverage by CUHK: Communications and Public Relations Office , Faculty of Engineering , Department of Surgery , CUHK in Touch , CUHK Alumni Magazine (news clipping) , CUHK Engineering Newsletter .) [Abstract & Full Text] Yin B†, Ho LWC†, Choi CHJ* . How do cells exocytose nanoparticles? Biochemistry , 62 , 15, 2229–2231 (2023). (Invited Viewpoint) [Abstract & Full Text] Han R†, Xiao Y†, Bai Q, Choi CHJ* . Self-therapeutic metal-based nanoparticles for treating inflammatory diseases. Acta Pharm. Sinica B , 13 , 5, 1847–1865 (2023). (Invited Review for the Special Issue on “Delivery nanotechnologies to modulate the immune system and combat inflammation and infection”.) [Abstract & Full Text] Zhang J, Shi H, Huang C, Mei L, Guo Q, Cheng K, Wu P, Su D, Chen Q, Gan S, Chan CKW, Shi J, Chen J, Choi CHJ , Yao S, Chen X-K, Tang BZ, He J, Sun H. De novo designed self-assembling rhodamine probe for real-time, long-term and quantitative live-cell nanoscopy. ACS Nano , 17 , 4, 3632–3644 (2023). [Abstract & Full Text] Sy KHS, Chan D, Chan R, Lyu J, Li Z, Wong KK-Y, Choi CHJ , Mok V, Lai H-M, Randlett O, Hu Y, Ko H. An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish. Nat. Commun. , 14 , 227 (2023). [Abstract & Full Text] (This work constitutes half of Sy KHS’s PhD thesis and Choi CHJ was the primary PhD thesis supervisor of Sy KHS.) Liu X, Zhou J, Wu H, Chen S, Zhang L, Tang W, Duan L, Wang Y, McCabe E, Hu M, Yu Z, Liu H, Choi CHJ , Sung JJ, Huang L, Liu R, Cheng AS. Fibrotic immune microenvironment remodelling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma. Mol. Ther. , 31 , 1, 119-133 (2023). [Abstract & Full Text] Yan D, Cui D, Zhu Y, Chan CKW, Choi CHJ , Liu T, Lee NPY, Law S, Tsao SW, Ma S, Cheung ALM. M6PR- and EphB4-rich exosomes secreted by serglycin-overexpressing esophageal cancer cells promote cancer progression. Int. J. Biol. Sci. , 19 , 2, 625–640 (2023). [Abstract & Full Text] Luo M, Li Y, Peng Bo, White J, Mäkilä; Tong WY*, Choi CHJ* , Day B*, Voelcker N*. A multi-functional porous silicon nanocarrier for glioblastoma treatment. Mol. Pharm. , 20 , 1, 545–560 (2023). [Abstract & Full Text] Bai Q, Xiao Y, Hong H, Cao X, Zhang L, Han R, Lee LKC, Xue EY, Tian XY*, Choi CHJ* . Scavenger receptor-targeted plaque delivery of microRNA-coated nanoparticles for alleviating atherosclerosis. Proc. Natl. Acad. Sci. USA , 119 , 39, e2201443119 (2022). (Coverage by MIMS Cardiology (news clipping) , RTHK Radio 1 Under The Sun Program , and several Hong Kong news outlets: Ming Pao (news clipping) , Oriental Daily News (news clipping) , Sky Post , Ta Kung Pao and Wen Wei Po (news clipping) . Also check out coverage by CUHK: Communications and Public Relations Office , Faculty of Engineering , CUHK Engineering newsletter , School of Biomedical Sciences .) [Abstract & Full Text] Luo M, Lee LKC, Peng B, Choi CHJ , Tong WY, Voelcker NH. Delivering the promise of gene therapy with nanomedicines in treating central nervous system diseases. Adv. Sci. , 9 , 26, 2201740 (2022). [Abstract & Full Text] Yan D, Cui D, Zhu Y, Chan CKW, Choi CHJ , Liu T, Tsao SW, Ma S, Cheung ALM. Serglycin-induced interleukin-1β from esophageal cancer cells upregulates hepatocyte growth factor in fibroblasts to promote tumor angiogenesis and growth. Clin. Transl. Med. , 12 , 8, e1031 (2022). [Abstract & Full Text] Chan CKW, Lau SHG, Choi CHJ* . Unbiased matchmaking. Nat. Chem. Biol. , 18 , 9, 921–923 (2022). (Invited News & Views) [Abstract & Full Text] Lee CW, Chen YF, Hsiao AWT, Wang AYF, Shen OYJ, Wang BYH, Ho LWC, Lin WT, Choi CHJ , Lee OKS. Demystifying the long noncoding RNA landscape of small EVs derived from human mesenchymal stromal cells. J. Adv. Res. , 39 , 73–88 (2022). [Abstract & Full Text] Li H, Ho LWC, Lee LKC, Liu S, Chan CKW, Tian XY, Choi CHJ* . Intranuclear delivery of DNA nanostructures via cellular mechanotransduction. Nano Lett. , 22 , 8, 3400–3409 (2022). [Abstract & Full Text] Ho LWC, Chan CKW, Han R, Lau YFY, Li H, Ho YP, Zhuang X, Choi CHJ* . Mammalian cells exocytose alkylated gold nanoparticles via extracellular vesicles. ACS Nano , 16 , 2, 2032–2045 (2022). [Abstract & Full Text] Lo CWS, Chan CKW, Yu J, He M, Choi CHJ , Lau JYW, Wong N. Development of CD44E/s dual-targeting DNA aptamer as nanoprobe to deliver treatment in hepatocellular carcinoma. Nanotheranostics , 6 , 2, 161–174 (2022). [Abstract & Full Text] Dai G, Choi CKK, Choi CHJ , Fong WP, Ng DKP. Glutathione-degradable polydopamine nanoparticles as a versatile platform for fabrication of advanced photosensitisers for anticancer therapy. Biomater. Sci. , 10 , 1, 189–201 (2022). [Abstract & Full Text] Liu H, Liu S, Xiao Y, Song W, Li H, Ho LWC, Shen Z, Choi CHJ* . A pH-reversible fluorescent probe for in situ imaging of extracellular vesicles and their secretion from living cells. Nano Lett. , 21 , 21, 9224–9232 (2021). [Abstract & Full Text] Han R, Ho LWC, Bai Q, Chan CKW, Lee LKC, Choi PCL, Choi CHJ* . Alkyl-terminated gold nanoparticles as a self-therapeutic treatment for psoriasis. Nano Lett. , 21 , 20, 8723–8733 (2021). (Coverage by MIMS Dermatology , RTHK Radio 1 Healthpedia Program , and 10 other Hong Kong news outlets: Ta Kung Pao , Oriental Daily News (news clipping) , Hong Kong Economic Times (news clipping) , Sky Post , Sing Tao Daily , HK01 , AM730 , Headline Daily , Bastille Post , Epoch Times HK . Also check out coverage by CUHK: Communications and Public Relations Office , Faculty of Engineering , CUHK in Touch , CUHKUpDates and CUHK eNews .) [Abstract & Full Text]
Dai G, Chu JCH, Chan CKW, Choi CHJ* , Ng DKP*. Reactive oxygen species-responsive polydopamine nanoparticles for targeted and synergistic chemo and photodynamic anticancer therapy. Nanoscale , 13 , 37, 15899–15915 (2021). [Abstract & Full Text] Liu Y, Choi CKK, Hong H, Xiao Y, Kwok ML, Liu H, Tian XY, Choi CHJ* . Dopamine receptor-mediated binding and cellular uptake of polydopamine-coated nanoparticles. ACS Nano , 15 , 13871–13890 (2021). (This paper became a finalist for the 2023 ACS Nano Impact Award , which honors a team of authors for their significant contributions to a research work published in ACS Nano in 2021 and 2022. There was one winner and four finalists around the world.) [Abstract & Full Text] Dai G†, Choi CKK†, Zhou Y, Bai Q, Xiao Y, Yang C, Choi CHJ* , Ng DKP*. Immobilizing a hairpin DNA-conjugated distyryl boron dipyrromethene on gold@polydopamine core-shell nanorods for microRNA detection and microRNA-mediated photodynamic therapy. Nanoscale , 13 , 6499–6512 (2021). [Abstract & Full Text] Ho LWC†, Yin B†, Dai G, Choi CHJ* . Effect of surface modification with hydrocarbyl groups on the exocytosis of nanoparticles. Biochemistry , 60 , 13, 1019–1030 (2021). (Invited Article for the Special Issue on “Biochemistry at the Nanoscale” .) [Abstract & Full Text] Yin B†, Ho LWC†, Liu S, Hong H, Tian XY, Li H, Choi CHJ* . Sub-10 nm substrate roughness promotes the cellular uptake of nanoparticles by upregulating endocytosis-related genes. Nano Lett. , 21 , 4, 1839–1847 (2021). [Abstract & Full Text] Lee LKC†, Leong LI†, Liu Y, Luo M, Chan HYE*, Choi CHJ* . Preclinical nanomedicines for polyglutamine-based neurodegenerative diseases. Mol. Pharm. , 18 , 2, 610-626 (2021). (Invited Review for the Special Issue on "Nanomedicines Beyond Cancer") [Abstract & Full Text] Choi CHJ* , Xiong MP*. Nanomedicines Beyond Cancer. Mol. Pharm. , 18 , 2, 475 (2021). (Invited Editorial for the Special Issue on “Nanomedicines Beyond Cancer” .) [Abstract & Full Text] Chiu YTE, Choi CHJ* . Enabling transgenic plant cell-derived biomedicines with nanotechnology. Adv. NanoBiomed Res. , 1 , 1, 2000028 (2021). (Invited Perspective for the inauguration of this journal.) [Abstract & Full Text] Guo Y, Zhang J, Pan G, Choi CHJ , Wang P, Li Y, Zhu X, Zhang C. Grafting multi-maleimides on antisense oligonucleotide to enhance its cellular uptake and gene silencing capability. Chem. Commun. , 56 , 54, 7439-7442 (2020). [Abstract & Full Text] Yin B, Chan CKW, Liu S, Hong H, Wong SHD, Lee LKC, Ho LWC, Zhang L, Leung KCF, Choi PCL, Bian L*, Tian XY*, Chan MN*, Choi CHJ* . Intrapulmonary cellular-level distribution of inhaled nanoparticles with defined functional groups and its correlations with protein corona and inflammatory response. ACS Nano , 13 , 12, 14048-14069 (2019). [Abstract & Full Text] Luo M, Lewik G, Ratcliffe JC, Choi CHJ , Mäkilä E, Tong WY, Voelcker NH. Systematic evaluation of transferrin-modified porous silicon nanoparticles for targeted-delivery of doxorubicin to glioblastoma. ACS Appl. Mater. Interfaces , 11 , 37, 33637-33649 (2019). [Abstract & Full Text] Chen Z†, Li H†, Zhang L, Lee CKY, Ho LWC, Chan CKW, Yang H, Choi CHJ* . Specific delivery of oligonucleotides to the cell nucleus via gentle compression and attachment of polythymidine. ACS Appl. Mater. Interfaces , 11 , 31, 27624-27640 (2019). [Abstract & Full Text] Chiu YTE†, Li H†, Choi CHJ* . Progress towards understanding the interactions between DNA nanostructures and the cell. Small , 15 , 26, 1805416 (2019). (Invited Review for the Special Issue on "Advances in DNA Nanotechnology" ). (This paper was chosen as the Inside Front Cover and was highlighted in MaterialsViews China . Top downloaded article in Small between 2018 and 2019.) [Abstract & Full Text] Ho LWC, Liu Y, Han R, Bai Q, Choi CHJ* . Nano-cell interactions of non-cationic bionanomaterials. Acc. Chem. Res. , 52 , 6, 1519-1530 (2019). (Invited Article for the Special Issue on “Nanomedicine and Beyond” and selected for the Special Issue on “First Accounts” that feature the first articles contributed by early career researchers to Acc. Chem. Res. : (See editorial here) ). (This paper was highlighted in X-molNews .) [Abstract & Full Text] Choi CKK†, Chiu YTE†, Zhuo X†, Liu Y, Pak CY, Liu X, Tse Y-L S; Wang J, Choi CHJ* . Dopamine-mediated assembly of citrate-capped plasmonic nanoparticles into stable core-shell nanoworms for intracellular applications. ACS Nano , 13 , 5, 5864-5884 (2019). (This paper was chosen as the Best Paper on Materials 2019 by the HKIE Materials Division and selected for a “Poster Presentation Award” at the 2019 GRC Plasmonically-Powered Processes .) [Abstract & Full Text] Zhang L, Tian XY, Chan CKW, Bai Q, Cheng CK, Chen FM, Cheung MSH, Yin B, Yang H, Yung W-Y, Chen Z, Ding F, Leung KCF, Zhang C, Huang Y, Lau JYW, Choi CHJ* . Promoting the delivery of nanoparticles to atherosclerotic plaques by DNA coating. ACS Appl. Mater. Interfaces , 11 , 15, 13888-13904 (2019). (Invited Forum Article for the Special Issue on "Translational DNA Nanotechnology" ). [Abstract & Full Text] Wong SHD†, Yin B†, Yang B, Lin S, Li R, Feng Q, Yang H, Zhang L, Yang Z, Li G, Choi CHJ* , Bian L*. Anisotropic nanoscale presentation of cell adhesion ligand enhances the recruitment of diverse integrins in adhesion structures and mechanosensing‐dependent differentiation of stem cells. Adv. Funct. Mater. , 29 , 8, 1806822 (2019). [Abstract & Full Text] Sy KHS, Ho LWC, Lau WCY, Ko H, Choi CHJ* . Morphological diversity, protein adsorption and cellular uptake of polydopamine-coated gold nanoparticles. Langmuir , 34 , 46, 14033-14045 (2018). [Abstract & Full Text] Yang H, Yao Y, Li H, Ho LWC, Yin B, Yung WY, Leung KCF, Mak AFT, Choi CHJ* . Promoting intracellular delivery of sub-25 nm nanoparticles via defined levels of compression. Nanoscale , 10 , 15090-15102 (2018). [Abstract & Full Text] To ACY†, Chu DHT†, Wang AR†, Li FCY, Chiu AWO, Gao DY, Choi CHJ , Kong SK, Chan TF, Chan KM, Yip KY. A comprehensive web tool for toehold switch design. Bioinformatics , 34 , 16, 2862-2864 (2018). [Abstract & Full Text] Choi CKK, Zhang L, Choi CHJ* . Efficient siRNA delivery with non-cationic carriers. Nat. Biomed. Eng. , 2 , 275-276 (2018). (Invited News & Views) [Abstract & Full Text] Ding F, Mou Q, Ma Y, Pan G, Guo Y, Tong G, Choi CHJ , Zhu X, Zhang C. Crosslinked nucleic acid nanogel for effective siRNA delivery and antitumor therapy. Angew. Chem. Int. Ed. , 57 , 12, 3064-3068 (2018). [Abstract & Full Text] Yin B†, Li KHK†, Ho LWC, Chan CKW, Choi CHJ* . Toward understanding in vivo sequestration of nanoparticles at the molecular level. ACS Nano , 12 , 3, 2088-2093 (2018). (Invited Perspective) [Abstract & Full Text] Chan CKW, Zhang L, Cheng CK, Yang H, Huang Y, Tian XY*, Choi CHJ* . Recent advances in managing atherosclerosis via nanomedicine. Small , 14 , 4, 1702793 (2018). [Abstract & Full Text] Choi CKK†, Zhuo X†, Chiu YTE, Yang H, Wang J, Choi CHJ* . Polydopamine-based concentric nanoshells with programmable architectures and plasmonic properties. Nanoscale , 9 , 16968-16980 (2017). [Abstract & Full Text] Li HY, Chen Z, Ho LWC, Chan PS, Li Q, Leung SC, Zhang B, Lai KL, Kwon GS, Choi CHJ , Lee TWY. Oligonucleotide-conjugated nanoparticles for targeted drug delivery via scavenger receptors class A: an in vitro assessment for proof-of-concept. Int. J. Pharm. , 532 , 1, 647-655 (2017). [Abstract & Full Text] Ho LWC, Yung WY, Sy KHS, Li HY, Choi CKK, Leung KCF, Lee TWY, Choi CHJ* . Effect of alkylation on the cellular uptake of polyethylene glycol-coated gold nanoparticles. ACS Nano , 11 , 6, 6085-6101 (2017). [Abstract & Full Text] Yang H, Chen Z, Zhang L, Yung WY, Leung KCF, Chan HYE, Choi CHJ* . Mechanism for the cellular uptake of targeted gold nanorods of defined aspect ratios. Small , 12 , 37, 5178-5189 (2016). [Abstract & Full Text] Li Q, Lai KL, Chan PS, Leung SC, Li HY, Fang Y, To KWK, Choi CHJ , Gao QY, Lee TWY. Micellar delivery of dasatinib for the inhibition of pathologic cellular processes of the retinal pigment epithelium. Colloids Surf. B , 140 , 278-286 (2016). [Abstract & Full Text] Choi CKK, Li J, Wei K, Xu YJ, Ho LWC, Zhu M, To KWK, Choi CHJ* , Bian L*. A gold@polydopamine core-shell nanoprobe for long-term intracellular detection of microRNAs in differentiating stem cells. J. Am. Chem. Soc. , 137 , 23, 7337–7346 (2015). [Abstract & Full Text]