Microfluidics Innovated
Bio-applications

Referred International Conference Proceedings

  1. C. Chang, Y. Ye, Q. Xiao, Y. P. Ho, A. C. Wei, "In silico simulation of metabolic regulation on mitochondrial dynamics in ageing," 9th WACBE World Congress in Bioengineering, Taipei, Taiwan, 2019.

  2. J. M. C. Guzman, Y. Garcia, Y. P. Ho, H. S. Chuang, "A Power-free colorimetric biochip for detection of mycobacterial topoisomerase enzyme activity," 9th WACBE World Congress in Bioengineering, Taipei, Taiwan, 2019.

  3. J. M. C. Guzman, Y. Garcia, Y. P. Ho, H. S. Chuang, "Development of rapid and sensitive quantification of low-concentration pathogens and its application on antimicrobial susceptibility test," 9th WACBE World Congress in Bioengineering, Taipei, Taiwan, 2019.

  4. O. Franch, M. Jepsen, H. Xiao, L. B. Marcussen, A. Jørgensen, C. Harmsen, A. Godbole, V. Nagaraja, Y. Wang, D. Shi, M. Stougaard, M. S. Hede, B. R. Knudsen and Y. P. Ho*, "Detecting Mycobacterial Infection via a Potential New Biomarker: the Activity of Essential Mycobacterial Enzymes," 17th Asia-Pacific Congress of Clinical Microbiology and Infection cum 8th International Infection Control Conference, Hong Kong, 2018. (Best Abstract for the category "Microbiology, diagnostics & genomics; Virology; Antimicrobial resistance")

  5. Q. Xiao, M. H. Rahman, S. Zhao and Y. P. Ho*, "Continuous Deformation of Cell Membrane On-Chip for Effective Cell Lysis," 22th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Kaohsiung, Taiwan, 2018.

  6. H. S. Ooi, T. K. Pang, M. H. Rahman, C. Wan and Y. P. Ho*, "Biopatterning of Stem/Progenitor Cells in Tissue-Mimicking Micro-Scaffold," 22th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Kaohsiung, Taiwan, 2018.

  7. C. Chang, Y. P. Ho and A. C. Wei, "Computational Model of Mitochondrial Metabolism and Dynamics in Ageing," The 1st International Mitochondria Meeting for Young Scientists, Kyoto, Japan, 2018. (Young Investigator Scholarships)

  8. C. Chang, Y. P. Ho and A. C. Wei, "Mathematical Modeling of Mitochondrial Quality Control in Mitochondrial Life Cycle and its Role in Ageing, " Single-Cell Biophysics: Measurement, Modulation, and Modeling, Biophysical Society Thematic Meeting, Taipei, Taiwan, 2017.

  9. X. Ma, M. L. Jepsen, A. Ivarsen, J. V. Nygaard, C. Tesauro, B. R. Knudsen, and Y. P. Ho*, "Intestinal Organoids Initiated in Microfluidics-based Double Emulsions," 20th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (MicroTAS), Dublin, Ireland, 2016.

  10. O. Franch, A. G. Jørgensen, M. B. Andersen, L. B. Marcussen, A. A. Godbole, R. Verma, V. Nagaraja, C. A. Guerrero, M. Stougaard, M. S. Hede, Y. P. Ho, B. R. Knudsen, "Tool for Sensitive and Specific Diagnosis of Tuberculosis with Perspective for Diagnosis in Low-Resource Settings," International Conference on Global Challenges in Neglected Tropical Diseases, León, Spain, 2016.

  11. M. L. Jepsen, O. Franch, A. G. Jørgensen, C. Harmsen, A. A. Godbole, V. Nagaraja, B. R. Knudsen, Y. P. Ho*, "Detecting the Activity of Mycobacterial Enzymes using a Quantum Dot based DNA Nanosensor," International Conference on Global Challenges in Neglected Tropical Diseases, León, Spain, 2016.

  12. M. L. Jepsen, C. Harmsen, O. Franch, M. Hede, B. R. Knudsen, Y. P. Ho*, "Quantum Dot Based DNA Nanosensor for the Detection of Mycobacterium Tuberculosis," The Biomedical Engineering Society Annual Meeting (BMES), Tampa, Florida, USA, 2015.

  13. O. Franch, A. G. Jørgensen, X. Ma, M. T. Bugge, S. Fjelstrup, M. Stougaard, B. R. Knudsen, M. S. Hede, Y. P. Ho*, "Topoisomerases as Biomarkers for Diagnosis of Infectious Diseases," EMBO Workshop on "DNA topoisomerases, DNA topology and human health", Les Diablerets, Switzerland, 2015.

  14. E. L. Kristoffersen, L. A. Jørgensen, A. G. Jørgensen, A. H. Andersen, Y. P. Ho, B. R. Knudsen, "Rolling Circle based Assay for Measuring Topoisomerase II Activity in Crude Cell Extracts, "EMBO Workshop on "DNA topoisomerases, DNA topology and human health", Les Diablerets, Switzerland, 2015.

  15. A. Ottaviani, C. Tesauro, S. Fjelstrup, R. F. Hougaard, P. Fiorani, A. Desideri, B. R. Knudsen, Y. P. Ho*, "Extraction of Active Enzymes from "Hard-to-Break-Cells": Evaluation by a RCA-based Assay," IEEE Sensors, Valencia, Spain, 2014.

  16. E. L. Kristoffersen, L. A. Jørgensen, A. G. Jørgensen, O. Franch, M. B. Andersen, Rikke Frøhlich, B. R. Knudsen, S. Juul, Y. P. Ho*, "Enzyme-based detection of infectious diseases in Point-of-Care settings," 248th ACS National Meeting, San Francisco, CA, USA, 2014.

  17. E. L. Kristoffersen, L. A. Jørgensen, A. G. Jørgensen, M. B. Andersen, O. Franch, M. Stougaard, B. R. Knudsen, Y. P. Ho*, "Analyzing Human Topoisomerase II Activity at the Single Catalytic Event Level," Gordon Research Conference - DNA Topoisomerases in Biology & Medicine, Newry, ME, USA, 2014.

  18. Y. Zhang, H. F. Chan, Y. P. Ho, Y. L. Chiu, L. You, K. W. Leong, "Monodispersed double emulsions as programmable microenvironment for cellular studies," Annual Meeting of the Society For Biomaterials, Denver, CO, USA, 2014.

  19. E. L. Kristoffersen, L. A. Jørgensen, A. G. Jørgensen, M. B. Andersen, M. Stougaard, B. R. Knudsen, Y. P. Ho*, "Analyzing Human Topoisomerase II Activity at the Single Catalytic Event Level by Creation of a Double Stranded Interlinked DNA Substrate," Workshop of Centre Européen de Calcul Atomique et Moléculaire (CECAM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 2014.

  20. G. Amselem, R. Tomasi, R. Frøhlich, Y. P. Ho, B. R. Knudsen, C. N. Baroud, "Integrated Microfluidic Device for Coupled Protein Expression and Drug Response on Individual Cancer Cells," 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Freiburg, Germany, 2013.

  21. E. L. Kristoffersen, A. Ottaviani, M. Juul Nielsen, M. B. Andersen, M. L. Jepsen, S. Juul and Y. P. Ho*, "Combining DNA Nanosensors and Droplet Microfluidics for Point-of-Care Diagnosis," International Conference on Nanoscience and Technology, China 2013 (ChinaNANO 2013), Beijing, China, 2013.

  22. S. Juul, Y. P. Ho, B. R. Knudsen and K. W. Leong, "Microfluidics-based Diagnosis-on-a-Chip by Enzyme Activity Detection," The Biomedical Engineering Society Annual Meeting (BMES), Seattle, USA, 2013.

  23. M. Lu, Y. P. Ho, C. L. Grigsby, A. A. Nawaz, K. W. Leong, and T. J. Huang, "A Milliseconds Microfluidic Chaotic Bubble Mixer for Polymer-DNA Nanocomplex Synthesis," The Biomedical Engineering Society Annual Meeting (BMES), Seattle, USA, 2013.

  24. J. Obliosca, S. Juul, Y. P. Ho, B. R. Knudsen, K. W. Leong Tim H.-C. Yeh, "NanoCluster Beacons as Reporters for Rolling Circle Enhanced Enzyme Activity Detection," The Biomedical Engineering Society Annual Meeting , Seattle, USA, 2013.

  25. M. Lu, Y. P. Ho, C. L. Grigsby, A. A. Nawaz, K. W. Leong, and T. J. Huang, "Polymer-DNA Nanocomplex Synthesis by "Microfluidic Drifting" Based Three-Dimensional Hydrodynamic Focusing Method," The Biomedical Engineering Society Annual Meeting (BMES), Seattle, USA, 2013.

  26. S. Juul, C. Harmsen, M. J. Nielsen, M. Stougaard, K. W. Leong, B. R. Knudsen and Y. P. Ho*, "Single Cell Enzyme Diagnosis on the Chip," 26th IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2013), Taipei, Taiwan, 2013.

  27. C. Grigsby, Y. P. Ho, A. Adler, K. W. Leong, "Microfluidic Manufacturing of Nanocomplexes Improves Nonviral Gene Delivery," The Biomedical Engineering Society Annual Meeting (BMES), Atlanta, USA, 2012.

  28. Y. P. Ho, S. Juul, M. Stougaard, J. Koch, F. F. Andersen, K. W. Leong, B. R. Knudsen, "Droplet-Microfluidics for Single Cell Enzyme Diagnostics", The Biomedical Engineering Society Annual Meeting (BMES), Atlanta, USA, 2012.

  29. Y. Zhang, Y. P. Ho, T. Schuhmann, B. Chlebina, L. C. You, K. W. Leong, "A selectively permeable microenvironment for integrative biology via microfluidics-assisted double emulsion," The Biomedical Engineering Society Annual Meeting (BMES), Atlanta, USA, 2012.

  30. H. F. Chan, Y. Zhang, Y. L. Chiu, Y. P. Ho, K. W. Leong, "Double-Emulsion Based Droplet Microfluidics as Bioreactor for Tissue Engineering Applications," The Biomedical Engineering Society Annual Meeting (BMES), Atlanta, USA, 2012.

  31. E. Roberts, Y. P. Ho, M. Kulis, A. Burks, K. W. Leong, "Engineered Biodegradable Microparticles for Well-Controlled Drug Delivery," The Biomedical Engineering Society Annual Meeting (BMES), Atlanta, USA, 2012.

  32. C. L. Grigsby, Y. P. Ho, K. W. Leong, "Confined assembly of polymer-nucleic acid nanocomplexes leads to improved performance," Gordon Research Conference - Drug Carriers in Medicine & Biology, Waterville NH, USA 2012.

  33. C. L. Grigsby, Y. P. Ho, K. W. Leong, "Cellular reprogramming with MAC-synthesized polyplexes," Duke Center for Biomolecular and Tissue Engineering Kewaunee Event, Durham NC, USA, 2012.

  34. Y. Zhang, Y. P. Ho, K. W. Leong, "Uniform Chitosan Microgels Prepared by Microfluidics-Aided Double Emulsion as Biodegradable Carriers," Gordon Research Conference - Drug Carriers in Medicine & Biology, Waterville NH, USA 2012.

  35. C. L. Grigsby, Y. P. Ho, K. W. Leong, "Advanced nanomanufacturing of polymer-nucleic acid complexes for cellular reprogramming," Whitaker International Program Meeting, New York NY, USA, 2012.

  36. C. L. Grigsby, Y. P. Ho, C. Lin, J. F. J. Engbersen, K. W. Leong, "Self-assembly of bioreducible nucleic acid nanocomplexes with microfluidics," BMES Annual Fall Scientific Meeting, Hartford, CT, USA, 2011.

  37. C. L. Grigsby, Y. P. Ho, K. W. Leong, "Synthesis of poly(amido amine)-nucleic acid nanocomplexes with microfluidics," North Carolina ACS Annual Meeting, Raleigh NC, USA, 2011.

  38. C. L. Grigsby, Y. P. Ho, K. W. Leong, "Properties of polymer-nucleic acid nanocomplexes synthesized with microfluidics-assisted confinement," Triangle Soft Matter Workshop, Chapel Hill, USA 2011.

  39. C. L. Grigsby, Y. P. Ho, K. W. Leong, "Improved synthesis of polymer-DNA nanocomplexes," Duke Synthetic Biology Symposium, Durham NC, USA, 2011.

  40. C. L. Grigsby, Y. P. Ho, K. W. Leong, "Reduced toxicity of nanocomplexes synthesized with microfluidics-assisted confinement," North Carolina Society of Toxicology Meeting, Research Triangle Park, NC, USA, 2011.

  41. Y. P. Ho, C. L. Grigsby and K. W. Leong, "Microfluidics-Assisted Synthesis of Gene-Loaded Nanocomplexes," Microfluidics, Physics & Chemistry of, Gordon Research Conference, Waterville Valley, USA, 2011.

  42. S. Juul, Y. P. Ho, M. Stougaard, J. Koch, F. F. Andersen, K. W. Leong, B. R. Knudsen, "Microfluidics-Mediated Isothermal Detection of Enzyme Activity at the Single Molecule Level," 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '11), Boston, USA, 2011.

  43. Y. P. Ho, C. L. Grigsby and K. W. Leong, "Unexpected Properties of Polymeric DNA-Nanocomplexes Synthesized in Picoliter Droplets," The 6th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE NEMS), Kaohsiung, Taiwan, 2011.

  44. Y. P. Ho, C. L. Grigsby, F. Zhao, H. Li, K. W. Leong, "DNA Nanocomplexes Synthesized in a Microfluidic Droplet Generator," The Biomedical Engineering Society Annual Meeting (BMES), Austin, USA, 2010.

  45. H. Li, Y. P. Ho, T. LaBean, K. W. Leong, "Self-assembling DNA Nanostructures: Novel Carriers for Drug Delivery," The Biomedical Engineering Society Annual Meeting (BMES), Austin, USA, 2010.

  46. C. L. Grigsby, Y. P. Ho, K. W. Leong, "Functional Performance of Polyplexes Self-Assembled in Microfludics-Generated Droplets," The Biomedical Engineering Society Annual Meeting (BMES), Austin, USA, 2010.

  47. Y. Wu, Y. Mao, Y. P. Ho, X. Wang, B. Yu, K. W. Leong, L. J. Lee, "The Study and Comparison of the Uptaking and Intracellular Trafficking of Lipoplex Nanoparticles and Polyplex Nanoparticles by Quantum Dots-FRET," American Institute of Chemical Engineers Annual Meeting, Salt Lake City, USA, 2010.

  48. Y. P. Ho, Y. Duan, F. Zhao, K. W. Leong, "Controlled Synthesis of DNA Nanocomplexes In A Microfluidic Device," Biophysical Society 54th Annual Meeting & 18th International Biophysics Congress, San Francisco, USA, 2010.

  49. Y. P. Ho, Y. Duan, F. Zhao, K. W. Leong, "Integration of Nanophotonics and Microfluidics: Controlled Synthesis and Real-Time Characterization of DNA Nanocomplexes for Gene Delivery," The Ninth Fitzparick Institute for Photonics Annual Meeting on Frontiers in Photonics Science and Technology, 2009.

  50. Y. P. Ho, H. H. Chen, K. W. Leong, T. H. Wang, "Spatially-Resolved Analysis of DNA Nanocomplex Self-Assembly Enabled by Integrating Nanophotonics and Microfluidics," Biophysical Society 53rd Annual Meeting & 17th International Biophysics Congress, Boston, USA, 2009.

  51. Y. P. Ho, H. H. Chen, K. W. Leong, T. H. Wang, "Quantitative Kinetic Analysis of DNA Nanocomplex Self-Assembly with Quantum Dots FRET in a Microfluidic Device," 21st IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS), Tucson, USA, 2008.

  52. Y. P. Ho, H. H. Chen, K. W. Leong, T. H. Wang, "Single Particle QD-FRET: Evaluation of the Stability and Composition of Nanocomplexes for Gene Delivery," The Eighth Fitzparick Institute for Photonics Annual Meeting on Frontiers in Photonics Science and Technology, 2008.

  53. H. H. Chen, Y. P. Ho, T. H. Wang, K. W. Leong, "Non-invasive Analysis of Nanocomplex and DNA Stability by Two-Step QD-FRET," 11th Annual Meeting of the American Society of Gene Therapy, Boston, USA, 2008.

  54. H. C. Yeh, Y. P. Ho, C. M. Puleo, T. H. Wang, "Using Tunable Cy5 Blinking Kinetics for Detection of Single-Nucleotide Differences," Biophysical Society 52nd Annual Meeting & 16th International Biophysics Congress, Long Beach, USA, 2008.

  55. H. H. Chen, Y. P. Ho, T.H. Wang, K.W. Leong, "Evaluating the Release and Integrity of DNA from Nanocomplexes for Gene Delivery by Two-Step QD-FRET," The Biomedical Engineering Society Annual Meeting (BMES), Los Angeles, USA, 2007.

  56. V. Bailey, T. C. Lim, Y. P. Ho, T. H. Wang, "Conjugation-Free Nanosensing by using Intercalating dyes in Quantum Dot Mediated FRET," The Biomedical Engineering Society Annual Meeting (BMES), Los Angeles, USA, 2007.

  57. H. H. Chen, Y. P. Ho, X Jiang, H. Q. Mao, T.H. Wang, K.W. Leong, "Quantitative Analysis of Intracellular unpacking of Polymeric DNA Nanoparticles Constructed from Quantum Dot-FRET," The 10th Annual Meeting of the American Society of Gene Therapy (ASGT), Seattle, USA, 2007.

  58. Y. P. Ho, K. Murray, T. H. Wang, "An Electrokinetic-based Sample Processing Chip for Concentration and Lysis of Cells," The Biomedical Engineering Society Annual Meeting (BMES), Chicago, USA, 2006.

  59. Y. P. Ho, T. H. Wang, "Multiplexed Detection of Anthrax Sequences with Quantum Dot Nanoprobes," IEEE/NLM Life Science Systems and Application Workshop (LSSA), NIH, Bethesda, USA, 2006.

  60. H. H. Chen, Y. P. Ho, T. H. Wang, K. W. Leong, "Quantitative Model of Intracellular Trafficking Constructed from Quantum-dot-FRET," The Biomedical Engineering Society Annual Meeting (BMES), Chicago, USA, 2006.

  61. H. C. Yeh, Y. P. Ho, C. M. Puleo, T. C. Lim, T. H. Wang, "Quantum Dot-FRET Nanosensors for Mutational Analysis of Cancers," The Biomedical Engineering Society Annual Meeting (BMES), Chicago, USA, 2006.

  62. Y. P. Ho, M. C. Kung, T. H. Wang, "Separation-free Detection of Low-abundant Biomolecules with Two-Color Colocalization of Quantum Dot Probes," Ninth International Conference on Miniaturized Chemical and Biochemical Analysis Systems (MicroTAS), Boston, USA, 2005.

  63. H. C. Yeh, Y. P. Ho, T. H. Wang, "Quantum Dot-Mediated Separation-Free Assay for Single Nucleotide Polymorphism (SNP) Detection," NSTI Bio-Nanotechnology Conference and Trade Show, 2005.

  64. H. H. Chen, Y. P. Ho, T. H. Wang, K. W. Leong, "Intracellular Trafficking of QD-FRET Nanoparticles for Gene Delivery," The Biomedical Engineering Society (BMES), Baltimore, USA, 2005.

  65. Y. P. Ho, M. Wu, H. Y. Lin, W. Fang, "A Robust and Reliable Stress-Induced Self-Assembly Mechanism for Optical Devices," Proceeding of IEEE/LEOS Optical MEMS, Lugano, Switzerland, 2002.

  66. W. Tang, M. Wu, Y. P. Ho, M. S. Yeh, W. Fang, "A novel MUMPs-compatible single-layer out-of-plane electrothermal actuator," Proc. SPIE, Smart Structures, Devices, and Systems. Melbourne, Australia, 2002.

  67. W. P. Lai, Y. P. Ho, W. Fang, "Novel Bulk Acoustic Wave Hammer to Determinate the Dynamic Response of Microstructures Using Pulsed Broad Bandwidth Ultrasonic Transducers," the ASME Proceedings of the International Mechanical Engineering Congress and Exhibition (IMECE), New York, USA, 2001.

  68. P. T. Liu, Y. P. Ho, S. H. Shen, S.-T. Tang, S.-T. Young, Weileun Fang, "Design of an acoustic wave actuator using Lorentz force," Proc. SPIE, Design, Characterization, and Packaging for MEMS and Microelectronics II, Adelaide, Australia, 2001.