Prof. XUE, Yang
Research Assistant Professor, Department of Biomedical Engineering, CUHK
E-mail: yangxue@cuhk.edu.hk
Location: MMW405
About
Yang received her B.Eng. degree in Pharmaceutical Engineering from Sichuan University in 2016 and completed her Ph.D. in Chemistry at The Chinese University of Hong Kong (CUHK) in 2020. Following her Ph.D., she worked as a Postdoctoral Fellow in the Department of Chemistry at CUHK. In August 2024, she joined the Department of Biomedical Engineering (BME) at CUHK as a Research Assistant Professor. Her research focuses on supramolecular and bioorthogonal chemistry, with applications in photodynamic therapy, cell-based immunotherapy, and targeted drug delivery.
Professional Education and Training
2020-2024 Postdoctoral Fellow, Department of Chemistry, The Chinese University of Hong Kong
2016-2020 PhD in Chemistry, Department of Chemistry, The Chinese University of Hong Kong
2012-2016 Bachelor of Engineering in Pharmaceutical Engineering, Sichuan University
Research Interest
Development of advanced photosensitizers for targeted photodynamic therapy;
Development of innovative strategies to modulate and detect cell-cell interactions and to facilitate cell-based immunotherapy;
Development of novel supramolecular and bioorthogonal approaches for various biomedical applications.
HONORS & AWARDS
2019 Certificate of Excellence in Professional Development Course for Teaching Assistants
2014 National Scholarship
2014 “Sheng Huaxi” First-class Scholarship
Selected Publications
1. Xue, E. Y.; Lee, A. C. K.; Chow, K. T.; Ng, D. K. P.* Promotion and Detection of Cell−Cell Interactions through a Bioorthogonal Approach. J. Am. Chem. Soc. 2024, 146, 17334−17347. (Supplementary Cover)
2. Xue, E. Y.; Yang, C.; Zhou, Y.; Ng, D. K. P.* A Bioorthogonal Antidote Against the Photosensitivity after Photodynamic Therapy. Adv. Sci. 2024, 11, 2306207.
3. Cao, Y.; Wong, R. C.; Xue, E. Y.; Zhang, H.; Wang, J.; Ding, Y.; Zhang, L.; Chen, F.; Wang, J.; Ng, D. K. P.* Immobilising an acid-cleavable dimeric phthalocyanine on gold nanobipyramids for intracellular pH detection and photodynamic elimination of cancer cells. Analyst 2024, 149, 3288−3292.
4. Zou, Q.; Liao, K.; Li, G.; Huang, X.; Zheng, Y.; Yang, G.; Luo M.; Xue, E. Y.; Lan, C.; Wang, S.; Yao, S.; Luo, D.;* Ng, D. K. P.;* Liu, Q.* Photo‐metallo‐immunotherapy: Fabricating Chromium‐Based Nanocomposites to Enhance CAR‐T Cell Infiltration and Cytotoxicity against Solid Tumors. Adv. Mater. 2024, 2407425.
5. Xue, E. Y.;# Kang, F.;# Zhou, Y.; Ng, D. K. P.* Design and Synthesis of a NAD(P)H:Quinone Oxidoreductase 1-Activatable Photosensitiser for Controlled Photodynamic Therapy. Chem. Commun. 2023, 59, 7056−7059.
6. Xiong, J.;# Xue, E. Y.;# Wu, Q.; Lo, P.-C.;* Ng, D. K. P.* A Tetrazine-Responsive Isonitrile-Caged Photosensitiser for Site-Specific Photodynamic Therapy. J. Controlled Release 2023, 353, 663−674.
7. Durán-Sampedro, G.;# Xue, E. Y.;# Moreno-Simoni, M.; Paramio, C.; Torres, T.;* Ng, D. K. P.;* de la Torre, G.* Glycosylated BODIPY-Incorporated Pt(II) Metallacycles for Targeted and Synergistic Chemo-Photodynamic Therapy. J. Med. Chem. 2023, 66, 3448−3459.
8. Liu, S.; Ma, J.; Xue, E. Y.; Wang, S.; Zheng, Y.; Ng, D. K. P.;* Wang, A.;* Zheng, N.* Polymeric Phthalocyanine-Based Nanosensitizers for Enhanced Photodynamic and Sonodynamic Therapies. Adv. Healthcare. Mater. 2023, 12, 2300481.
9. Xiong, J.; Xue, E. Y.; Ng, D. K. P.* Synthesis, Cellular Uptake, and Photodynamic Activity of Oligogalactosyl Zinc(II) Phthalocyanines. ChemPlusChem, 2023, 88, e202200285 (Front cover)
10. Xue, E. Y.; Yang, C.; Fong, W.-P.; Ng, D. K. P.* Site-Specific Displacement-Driven Activation of Supramolecular Photosensitizing Nanoassemblies for Antitumoral Photodynamic Therapy. ACS Appl. Mater. Interfaces 2022, 14, 14903−14915.
11. Casellas, N. M.; Dai, G.; Xue, E. Y.; Vicente-Arana, M. J.; Ng, D. K. P.;* Torres, T.;* García-Iglesias, M.* Porphyrin-Based Supramolecular Nanofibres as a Dynamic and Activatable Photosensitiser for Photodynamic Therapy. Biomater. Sci. 2022, 10, 3259−3267.
12. Xue, E. Y.; Shi, W.-J.; Fong, W.-P.; Ng, D. K. P.* Targeted Delivery and Site-Specific Activation of β-Cyclodextrin-Conjugated Photosensitizers for Photodynamic Therapy through a Supramolecular Bio-Orthogonal Approach. J. Med. Chem. 2021, 64, 15461–15476.
13. Xue, E. Y.; Wong, R. C. H.; Wong, C. T. T.; Fong, W.-P.; Ng, D. K. P.* Synthesis and Biological Evaluation of an Epidermal Growth Factor Receptor-Targeted Peptide-Conjugated Phthalocyanine-Based Photosensitiser. RSC adv. 2019, 9, 20652−20662.