Core Faculty Members

Prof. CHANG Hing-Chiu Charles
曾慶昭教授
Assistant Professor, Department of Biomedical Engineering, CUHK

Area of Expertise: Diagnostic Medical Imaging, Fast Magnetic Resonance Imaging, Diffusion-Weighted Imaging

hcchang@cuhk.edu.hk
Tel: 3943 8342
Location: ERB1112

Lab webpage: http://www.bme.cuhk.edu.hk/mrilab

Charles Hing-Chiu Chang received his PhD degree in Biomedical Electronics from the National Taiwan University in 2012, and completed his postdoc training at Duke University Medical Center. Before joining the academia, he worked in a medical imaging industry and developed prototype magnetic resonance imaging (MRI) software for research purpose. He has pioneered several 2D and 3D multi-shot EPI techniques to enable high-resolution and time-efficient brain diffusion-tensor imaging (DTI), such as 2D DTI based on multi- band interleaved EPI with multiplexed sensitivity encoding (MB-MUSE), 3D DTI based on interleaved EPI acquisition and multiplexed sensitivity encoding and reconstruction (3D-MUSER), self-calibrated and collaborative Propeller-EPI Reconstruction (SCOPER). Furthermore, he is practically interested in clinical application and routine examination of MRI, and has been actively working with radiologists on exploring new applications in diagnosis using advanced MRI techniques. In July 2021, he joined the Department of Biomedical Engineering in the Chinese University of Hong Kong as Assistant Professor.

2012 Ph.D. in Biomedical Electronic, National Taiwan University, Taiwan
2006 M.S. in Electrical Engineering, National Taiwan University, Taiwan
2004 B.S. in Electrical Engineering, National Taiwan University, Taiwan

· Development of three-dimensional (3D) diffusion-weighted imaging (DWI) techniques for high-resolution neural fiber mapping
· Development of advanced abdominal DWI techniques for the application of free-breathing liver DWI
· Clinical applications of MRI fat-water imaging techniques
· Image reconstruction and artifact reduction for fast MRI techniques (e.g., echo-planar imaging)
· MRI-guided applications with the use of real-time data feedback

BMEG2001/BMEG5710 Introduction to Biomedical Engineering
BMEG3103 Big Data in Healthcare
BMEG3420 Medical Robotics
BMEG4320 AI & Imaging for Biomedical Engineering
BMEG4520 Cardiovascular Engineering

1. Liu YJ, Liu SC, Liao CH, Peng SL, Lu YX, Hsieh CF, Lee CH, Tsai MT, Juan CJ, Li YH*, Chang HC*, MUSE and PROPELLER DWI for ADC in parasagittal dura: insights from high-resolution and reduced-distortion DWI, Scientific Reports, 2025;15, 7473, [25/134=18.7%, MULTIDISCIPLINARY SCIENCES, Citation:0, IF=3.8]

2. Yuan C, Chen S, Liang L, Xu X, Xiong H, Li Y, Liu T, Chen NK, Chang HC*, High‐resolution and high‐fidelity diffusion tensor imaging of cervical spinal cord using 3D reduced‐FOV multiplexed sensitivity encoding (3D‐rFOV‐MUSE), Magn Reson Med. 2025; 94:166-182, [52/204=25.2%, RADIOLOGY NUCLEAR MEDICINE & MEDICAL IMAGING, Citation:0, IF=3.0]

3. Zhang T, Yuan S, Xu C, Liu P, Chang HC, Ng SH, Ren H, Yuan W*, Pneumaoct: Pneumatic optical coherence tomography endoscopy for targeted distortion-free imaging in tortuous and narrow internal lumens, Science Advances, 2024;10, eadp3145, [11/134=8.2%, MULTIDISCIPLINARY SCIENCES, Citation:14, IF=11.7]

4. Chen S, Chu ML, Liang L, Liu YJ, Chen NK, Wang H, Juan CJ, Chang HC*, Highly accelerated multi‐shot intravoxel incoherent motion diffusion‐weighted imaging in brain enabled by parametric POCS‐based multiplexed sensitivity encoding, NMR in Biomedicine, 2024 Mar;37(3):e5063, [11/44=23.9%, SPECTROSCOPY, Citation:1, IF=2.7]

5. Dai J, Zhu B, Wang X, Jiang Z, Wu M, Liang L, Xie X, Lam J, Chang HC, Kwok KW*, Learning-based Efficient Phase-Amplitude Modulation and Hybrid Control for MRI-guided Focused Ultrasound Treatment, IEEE Robotics and Automation Letters, 2024 Feb;9(2):995-1002, [12/46=25%, ROBOTICS, Citation:1, IF=4.6]

6. He Z, Dai J, Ho JDL, Tong HS, Wang X, Fang G, Liang L, Cheung CL, Guo Z, Chang HC, Iordachita I, Taylor R, Poon WS, Chan D, Kwok KW*, Interactive Multi‐Stage Robotic Positioner for Intra‐Operative MRI‐Guided Stereotactic Neurosurgery, Advanced Science, 2024 Feb;11, 2305495, [29/439=6.5%, MATERIALS SCNENCE MULTIDISCIPLINARY, Citation:3, IF=14.3]

7. Cheung CL, Wu M, Fang G, Ho JDL, Liang L, Tan KV, Lin FH, Chang HC, Kwok KW*, Omnidirectional Monolithic Marker for Intraoperative MR-based Positional Sensing in Closed MRI, IEEE Transactions on Medical Imaging, 2024 Jan;43(1):439-448, [7/204=3.2%, RADIOLOGY NUCLEAR MEDICINE & MEDICAL IMAGING, Citation:2, IF=8.9]

8. Wang L, Li T, Cai J, Chang HC*. “Motion-resolved four-dimensional abdominal diffusion-weighted imaging using PROPELLER EPI (4D-DW-PROPELLER-EPI)”. Magn Reson Med. 2023 Dec;90(6):2454-2471, [52/204=25.2%, RADIOLOGY NUCLEAR MEDICINE & MEDICAL IMAGING, Citation:1, IF=3.0]

9. Liu CH, Chang HC, Liu YJ, Lin WC, Hsieh CF, Lin TP, Juan CH, TL W, Juan CJ*. “Accumulated Hepatic Steatosis Grades Predicted by T2*-IDEAL Fat Fraction”. J. Med. Biol. Eng. 43, 706–714 (2023), [95/123=76.8%, ENGINEERING BIOMEDICAL, Citation:0, IF=1.6]

10. Xiao H, Han X, Zhi S, Wong YL, Liu C, Li W, Liu W, Wang W, Zhang Y, Wu H, Lee HV, Cheung LA, Chang HC, Liao YP, Deng J, Li T, Cai J*. “Ultra-fast multi-parametric 4D-MRI image reconstruction for real-time applications using a downsampling-invariant deformable registration (D2R) model”. Radiother Oncol. 2023 Dec;189:109948. [20/204=9.6%, RADIOLOGY NUCLEAR MEDICINE & MEDICAL IMAGING, Citation:3, IF=4.9]

11. Li YH, Lin SC, Chung HW, Chang CC, Peng HH, Huang TY, Shen WC, Tsai CH, Lo YC, Lee TY, Juan CH, Juan CE, Chang HC*, Liu YJ*, Juan CJ*. “The role of input imaging combination and ADC threshold on segmentation of acute ischemic stroke lesion using U-Net”. European Radiology. 2023 Sep;33(9):6157-6167. [14/203=6.4%, RADIOLOGY NUCLEAR MEDICINE & MEDICAL IMAGING, Citation:1, IF=5.9]

12. Liu X, Chen S, Cui D, Hui ES, Chan Q, Chen NK and Chang HC*, “A robust self-referenced 2D nyquist ghost correction for different MRI-biomarker measurements based on multi-band interleaved EPI”. Frontier in Physics, 10:1057572, 2023. [42/111=37.4%, PHYSICS MULTIDISCIPLINARY, Citation:2, IF:3.1]

13. Fang G, Wang X, Ho JDL, Wang K, Chow CK, Lee KH, Xie X, Tang WL, Liang L, Chang HC, Juan CJ, Liu YH, Chan JYK, Kwok KW*, “Epipolar Geometry‐Based Visual Servoing of Soft Endoscopic Manipulator for Transoral Laser Ablation”.Advanced Intelligent Systems, 4 (12), 2200197, 2022. [19/82=22.6%, AUTOMATION & CONTROL SYSTEM, Citation:3, IF:7.4]

14. Tan KV*, Yang X, Chan CY, Shi J, Chang HC, Chiu KW, Man K. “Non-invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma”. J Vis Exp. 2022 Aug 31;(186). [72/134=53.4%, MULTIDISCIPLINARY SCIENSE, 20%, Citation:2, IF:1.2]

15. Hui RW, Chiu KW, Mak LY, Chang HC, Cheung KS, Fung J, Yuen MF, Seto WK*. “Magnetic resonance imaging metrics and the predictability of adverse outcomes in on-treatment Asian chronic hepatitis B”. J Gastroenterol Hepatol. 2022 Jun;37(6):1139-1147.

16. Z Dong, Wang X, Fang G, He Z, Ho JDL, Cheung CL, Tang WL, Xie X, Liang L, Chang HC, Ching CK, Kwok KW*. "Shape Tracking and Feedback Control of Cardiac Catheter Using MRI-Guided Robotic Platform—Validation With Pulmonary Vein Isolation Simulator in MRI," in IEEE Transactions on Robotics, vol. 38, no. 5, pp. 2781-2798, Oct. 2022. [5/42=10.7%, ROBOTICS, Citation:35, IF:7.8]

17. Chang HC, Chen G, Chung HW, Wu PY, Liang L, Juan CJ, Liu YJ, Tse MD, Chan A, Zhang S, and Chiu KW*, “Multi-shot Diffusion-Weighted MRI with Multiplexed Sensitivity Encoding (MUSE) in the Assessment of Active Inflammation in Crohn’s Disease”, Journal of Magnetic Resonance Imaging, 2022;55:128-137, [42/204=25.1%, RADIOLOGY NUCLEAR MEDICINE & MEDICAL IMAGING, Citation:20, IF=3.3]

18. Välimäki M*, Yang M, Lam YTJ, Lantta T, Palva M, Palva S, Yee B, Yip SH, Yu KD, Chang HC, Cheng PYI, Bressington D. “The impact of video gaming on cognitive functioning of people with schizophrenia (GAME-S): study protocol of a randomised controlled trial”. BMC Psychiatry. 2021 Jan 18;21(1):46. [79/279=20.6%, PSYCHIATRY, Citation:15, IF=3.4]

19. Chen HC, Yang HC, Chen CC, Harrevelt S, Chao YC, Lin JM*, Yu WH, Chang HC, Chang CK, Hwang FN. “Improved Image Quality for Static BLADE Magnetic Resonance Imaging Using the Total-Variation Regularized Least Absolute Deviation Solver”. Tomography. 2021 Oct 8;7(4):555-572. doi: 10.3390/tomography7040048. PMID: 34698286; PMCID: PMC8544655. [100/203=49%, RADIOLOGY NUCLEAR MEDICINE & MEDICAL IMAGING, Citation:5, IF=1.9]

20. Fang G, Chow MCK, Ho JDL, He Z, Wang K, Ng TC, Tsoi JKH, Chan PL, Chang HC, Chan DT, Liu YH, Holsinger FC, Chan JY, Kwok KW*. “Soft robotic manipulator for intraoperative MRI-guided transoral laser microsurgery”. Sci Robot. 2021 Aug 18;6(57):eabg5575. [1/42=1.7%, ROBOTICS, Citation:115, IF:25.0]