The Biomaterials and Stem Cell Tissue Engineering Laboratory (BSCTEL) is dedicated to the development of novel biomaterials for assisting biological studies and enhancing clinical therapies. Specific research directions include:
Functional biomaterials for regenerative medicine:
bio-functional polymeric biomaterial scaffolds for tissue engineering applications: biomimetic materials to present microenvironmental cues to guide cell/tissue development
physically functional biomaterials for clinical applications: mechanically robust, injectable and stimuli-responsive materials
nanomaterials for gene/drug delivery and molecular imaging/detection
Stem cell tissue engineering
investigate the role of microenvironment cues including mechanical forces, cell-scaffold interactions and biochemical factors on cellular function, tissue structure and development
explore the regulatory mechanisms of musculoskeletaltissue mineralization
advance stem cell-based tissue engineering technologies for cartilage and other musculoskeletal tissues
Novel supramolecular hydrogels are injectable, malleable, and mechanically robust.
Novel supramolecular hydrogels are mechanically robust (a, b), injectable and self-healing (c), bioadhesive (d), facilitate cell infiltration (e), and harbor small molecular drugs (f,g)
(Feng, Wei, et al., Biomaterials, 2016)
Hydrogels Functionalized with N-cadherin Mimetic Peptide Enhance Osteogenesis of hMSCs by Emulating the Osteogenic Niche. (Zhu, et al., Biomaterials, 2016)
Stem cell-laden hydrogels that are functionalized with N-cadherin peptide enhance calvarial bone defect repair.
intracellular detection of osteogenic marker miRNAs in living differentiating stem cells.
Choi, et al., JACS, 2015
Multifunctional nanocarrier of drugs/genes to enhance stem cell differentiation and enable long term in vivo tracking of stem cells. (Li, et al., Adv Healthcare Materials, 2015)
Dr. Li Jinming
Co-delivery of small molecules and siRNA in multifunctional nanocarrier for enhancing the chondrogenesis of hMSCs, and subsequently stabilizing the chondrogenic phenotype of the differentiated hMSCs. (Xu, Li, et al., Adv Functional Materials, 2016)
Novel supramolecular hydrogels are mechanically robust, fatigue resistant, and resistant to cutting by a scalpel.