Journal publications

(*corresponding author, +equal contribution)

  1. +Zhang, K.; +Jia, Z.; Yang, B.; Feng, Q.; Xu, X.; Yuan, W.; Li, X.; Chen, X.; Duan, L.; *Wang, D.; *Bian, L. Adaptable hydrogels mediate cofactor-assisted activation of biomarker-responsive drug delivery via positive feedback for enhanced tissue regeneration. Advanced Science, accepted.
  2. +Kang, H.; +Zhang, K.; Pan, Q.; Lin, S.; Wong, S.H.D.; Li, J.; Lee, Y. W.; Yang, B.; Han, F.; *Li, B.; *Bian, L. Remote control of intracellular calcium using upconversion nanotransducers regulates stem cell differentiation in vivo. Advanced Functional Materials, accepted.  
  3. Li, J.; Lee, Y. W.; Wu, T.; Leung, Y.T.C; Xu, J.; Wong, S.H.D.; Li, R.; *Li, G.; *Tang, B.Z.; *Bian, L. Detection of matrix metallopeptidase 13 for monitoring stem cell differentiation and early diagnosis of osteoarthritis by fluorescent light-Up probes with aggregation-induced emission characteristics. Advanced Biosystems, accepted.
  4. +Chen, X.; +Dong, C.; +Wei, K.; +Yao, Y.; et al., Feng, Q.; Zhang, K.; Mak, A.; *Bian, L. Supramolecular hydrogels cross-linked by preassembled host-guest PEG cross-linkers resists excessive, ultrafast, and non-resting cyclic compression. NPG Asia Mater. 2018, accepted.
  5. +Kang, H.; Jung, H.J.; Kim, S.K.; Wong, S.H.D.; Lin, S.; Li, G.; Dravid, V.; *Bian, L. Magnetic manipulation of reversible nanocaging controls in vivo adhesion and polarization of macrophages. ACS Nano, 2018 May 22.
  6. +Li, R.; +Li, J.; Xu, J.; Wong, S.H.D.; Chen, X.; Yuan, W.; *Bian, L. Multiscale reconstruction of a synthetic biomimetic micro-niche for enhancing and monitoring the differentiation of stem cells. Biomaterials, 2018,173:87-99.
  7. +Kang, H.; + Jung, H.J.; Wong, S.H.D.; Kim, S.K.; Lin, S.; Chan, K.F.; Zhang, L.; Li, G.; Dravid, V.; *Bian, L. Remote control of heterodimeric magnetic nanoswitch regulates the adhesion and differentiation of stem cells. J. Am. Chem. Soc., 2018;140 (18): 5909-5913.
  8. +Kang, H.; +Zhang, K.; Wong, S.H.D.; et al.; *Bian, L. Near-infrared light-controlled regulation of intracellular calcium to modulate macrophage polarization. Biomaterials, 2018 Apr. pii: S0142-9612(18) 30166-2.
  9. Zhu, M.; Wei, K.; Lin, S.; Wu, C.C.; *Li, G.; *Bian, L. Bio-adhesive polymersome for localized and sustained drug delivery at pathological sites with harsh enzymatic and fluidic environment via supramolecular host-guest complexation. Small,  2018 Feb;14(7).
  10. Chen, H.; Yan, X.; Feng, Q.; Zhao, P.; Xu, X. Ng, D. H.L.; *Bian, L. Citric acid/cysteine modified cellulose-based materials: green preparation and its applications in anti-counterfeiting, chemical Sensing, and UV shielding. ACS Sustain. Chem. Eng. 2017, 5 (12), 11387–11394.
  11. Zhao, P.; Wei, K.; Feng, Q.; Chen, H.; Wong, S.H.D.; Chen, X.; Wu, C.C.; *Bian, L. Mussel-mimetic hydrogels with defined cross-linkers achieved by controlled catechol dimerization exhibiting tough adhesion for wet biological tissues. Chemical Communications, 2017, 53, 12000-12003.  
  12. Feng, Q.; Wei, K.; Zhang, K.; Yang, B.; Tian, F.; Wang, G.; *Bian, L. One-pot solvent exchange preparation of non-swellable, thermoplastic, stretchable, and adhesive supramolecular hydrogels based on dual synergistic physical crosslinking. NPG Asia Mater.  2018, 10, e455.
  13. +Kang, H.; +Kim, M.; +Feng, Q.; Lin, S.; Wei, K.; Li, R.; Choi, C. J.; Kim, T.; Li, G.; *Oh, J. M.; *Bian, L. Nanolayered hybrid mediates synergistic co-delivery of ligand and ligation activator for inducing stem cell differentiation and tissue healing. Biomaterials , 2017, 149:12-28.
  14. +Zhang, K.; +Lin, S.; Feng, Q.; Dong, C.; Yang, Y.; *Li, G.; *Bian, L. Bioactive nanocomposite hydrogels stabilized by self-assembled multivalent bisphosphonate-magnesium nanoparticles mediate sustained release of magnesium ion and promote in-situ bone regeneration. Acta Biomaterialia 2017 Sep, S1742-7061(17)30611-6.
  15. Wei, K.; Chen, X.; Li, R.; Feng, Q.; *Bian, L. Multivalent host-guest hydrogels as fatigue resistant 3D matrix for excessive mechanical stimulation of encapsulated cells. Chem. Mater.  2017, 29 (20), 8604-8610.
  16. +Kang, H.; +Kim, S.; Wong, S.H.D.; Jung, H.J.; Lin, Si.; Zou, K.; Li, R.; Li, G.; *Dravid, V.; *Bian, L. Remote manipulation of ligand nano-oscillations regulates adhesion and polarization of macrophages in vivo. Nano Letters, 2017, 17 (10), 6415-6427
  17. +Kang, H.; +Wong, S.H.D.; Yan, X.; Jung, H.J.; King, S.K.; Lin, Si.; Wei, K.; Li, G.; *Dravid, V.; *Bian, L. Remote control of multi-Modal nanoscale ligand oscillations regulates stem cell adhesion and differentiation". ACS Nano, 2017, 11 (10), 9636-9649.
  18. +Li, R.; +Xu, J.; Wong, S.H.D.; Li, J.; Zhao, P.; *Bian, L.; Self-assembled N-cadherin mimetic peptide hydrogels promote the chondrogenesis of mesenchymal stem cells through inhibition of canonical Wnt/β-catenin signaling. Biomaterials, 2017, 145: 33-43.
  19. +Ouyang, X.; +Zhang, K.; Wu, J.; Wong, S.H.D.; Feng, Q.; *Bian, L.; *Zhang, A. Optical μ-Printing of Cellular-Scale Microscaffold Arrays for 3D Cell Culture, Scientific Report,  2017 Aug 21;7(1):8880.
  20. Zhang, K.; Feng, Q.; Xu, J.; Xu, X.;  Yeung, K.W.K.; *Bian, L. Self-assembled injectable nanocomposite hydrogels stabilized by bisphosphonate-magnesium (Mg2+) coordination regulates the differentiation of encapsulated stem cells via dual crosslinking. Advanced Functional Materials. 2017, 27, 1701642.
  21. Li, J.; Yan, X.; Leung, Y.T.C; Wong, S.H.D.; Xu, J.; Li, R.; Zhao, Y.; Yung, Y.Y.C; Zhao, E.; *Tang, B.Z.; *Bian, L. Photo-controlled siRNA delivery and biomarker-triggered AIEgen emission by upconversion NaYF4:Yb3+Tm3+@SiO2 nanoparticles for inducing and monitoring stem cell differentiation. ACS Appl. Mater. Interfaces, 2017 March.
  22. +Wong, S.H.D.; +Li, J.; Yan, X.; Wang, B., Zhang, L.; *Bian, L. Magnetically tuning tether mobility of integrin ligand regulates adhesion, spreading, and differentiation of stem cells. Nano Letters, 2017; 17 (3), 1685-1695
  23. +Feng, Q.; +Lin, S..; Zhang, K.; Dong, C.,  Sun, Y.; Huang, H.; Yan, X.; Zhang, L.; Li, G.; *Bian, L. Sulfated hyaluronic acid hydrogels with retarded degradation and enhanced growth factor retention promote hMSC chondrogenesis and articular cartilage integrity with reduced hypertrophy. Acta Biomaterialia, 2017 Apr 15;53:329-342
  24. +Xu, Y.; +Wei, K.; Zhao, P.; Feng, Q.; Choi, C.K. ; *Bian, L. Preserving the adhesion of catechol-conjugated hydrogels by thiourea-quinone coupling. Biomaterials Science, 2016, 4, 1726-1730.
  25. +Li, J.; +Lee, Y. W.; Wu, T.; Xu, J.; Zhang, K.; Wong, S.H.; Li, R.; *Li, G.; *Bian, L. Near-infrared light-triggered release of small molecules for controlled differentiation and long-term tracking of stem cells in vivo using upconversion nanoparticles. Biomaterials, 2016 Dec;  110: 1-10
  26. Zhu, M.; Feng, Q.; Sun, Y.; Li, G.; *Bian, L. Effect of cartilaginous matrix components on the chondrogenesis and hypertrophy of mesenchymal stem cells in hyaluronic acid hydrogels. Journal of Biomedical Materials Research Part B.  2017 Nov;105(8):2292-2300.
  27. +Feng, Q.; +Wei, K.; Lin, S.; Xu, Z.; Sun, Y.; Shi, P.; Li, G.; *Bian, L. Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration. Biomaterials, 2016 Sept, 101: 217-28.
  28. Huang, H.; Xu, J.; Wei, K.; Xu, Y.; Choi, C. K; Zhu, M.; *Bian, L. Bioactive nanocomposite poly (ethylene glycol) hydrogels crosslinked by multifunctional layered double hydroxides nano-crosslinkers. Macromolecular Bioscience, 2016; 16 (7): 1019-26
  29. +Xu, J.; +Li, J.;  Lin, S.; Wu, T.; Huang, H.; Zhang, K.; Su, Y.;  Yeung, K.W.K.; Li, G.; *Bian, L. Nanocarrier-mediated codelivery of small molecular drugs and siRNA to enhance chondrogenic differentiation and suppress hypertrophy of human mesenchymal stem cells. Advanced Functional Materials. 2016; 26 (15): 2463-72.
  30. Wei, K.; Zhu, M.; Su, Y.; Xu, J.; Feng, Q.; Lin, S.; Wu, T.; Xu, J.; Tian, F.; Xia, J.; Li, G.; *Bian, L. Robust biopolymeric supramolecular “Host-Guest Macromer” hydrogels reinforced by in situ formed multivalent nanoclusters for cartilage regeneration. Macromolecules, 2016 Jan, 49 (3), pp 866–875.
  31. Li, J.; Lee, Y. W.; Wu, T.; Xu, J.; Zhang, K.; Li, G.; Xia, J.; *Bian, L. Multifunctional quantum dot nanoparticles for effective differentiation and long-term tracking of human mesenchymal stem cells in vitro and in vivo. Advanced Healthcare Materials, 2016 May;5(9):1049-57.
  32. Zhu, M.; Lin, S.; Sun, Y.; Feng, Q.; Li, G.; *Bian, L. Hydrogels functionalized with N-cadherin mimetic peptide enhance osteogenesis of hMSCs by emulating the osteogenic niche. Biomaterials, 2016 Jan, Vol.77: 44–52
  33. Choi, C.K.; Xu, Y.; Wang, B.; Zhu, M.; Zhang, L.; *Bian, L. Substrate coupling strength of integrin-binding ligands modulates adhesion, spreading, and differentiation of Human mesenchymal stem cells. Nano Letters, 2015 Oct 14;15(10):6592-600.
  34. Choi, C.K.; Li, J.; Wei, K.; Xu, Y.; Ho, L.W.; Zhu, M.; To, K.W.; *Choi, C.H.; *Bian, L. A gold@polydopamine core-shell nanoprobe for long-term intracellular detection of microRNAs in differentiating stem cells. J. Am. Chem. Soc.,  2015 Jun 17;137(23):7337-46.
  35. Bian, L.; Mak, A.F.T.; Wu, Chi; Cheng C.Y.; Gu, Z.W.; Zhang, X.D.; *Qin, L. A model for facilitating translational research and development in China. Journal of Orthopaedic Translation, 2014 August, 2(4), 170-176
  36. +Feng, Q.; +Zhu, M.; Wei, K.; *Bian, L. Cell-mediated degradation regulates human mesenchymal stem Cell chondrogenesis and hypertrophy in MMP-sensitive hyaluronic acid hydrogels. PLoS ONE, 2014 Jun 9;9(6)  
  37. +Zhu, M.; +Feng, Q.; *Bian, L. Differential effect of hypoxia on human mesenchymal stem cell chondrogenesis and hypertrophy in hyaluronic acid hydrogels.  Acta Biomaterialia  2014 Mar;10(3):1333-40.
  38. Bian, L.; Guvendiren, M.; Mauck, R.L.; Burdick, J.A.  Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis. Proc. Natl. Acad. Sci. USA  2013 Jun 18;110(25):10117-22. PMID: 23733927
  39. Bian, L.; Hou, C., Tous, E.; Rai R.; Mauck, R.L.; Burdick, J.A. The Influence of Hyaluronic Acid Hydrogel Crosslinking Density and Macromolecular Diffusivity on Human MSC Chondrogenesis and Hypertrophy. Biomaterials. 2013 Jan;34(2):413-21.
  40. Bian, L.; Zhai, D.Y.; Tous, E.; Rai R.; Mauck, R.L.; Burdick, J.A. Enhanced MSC chondrogenesis following delivery of TGF-beta3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo. Biomaterials. 2011 Sep; 32(27):6425-34.
  41. Bian, L.; Zhai, D.Y.; Zhang, E.C.; Mauck, R.L.; Burdick, J.A. Dynamic compressive loading enhances cartilage matrix synthesis and distribution and suppresses hypertrophy in hMSC-laden hyaluronic acid hydrogels. Tissue Engineering Part A. 2012 Apr;18(7-8):715-24. PMID: 21988555
  42. Bian, L.; Zhai, D.Y.; Mauck, R.L.; Burdick, J.A. Coculture of human mesenchymal stem cells and articular chondrocytes reduces hypertrophy and enhances functional properties of engineered cartilage. Tissue Engineering Part A. 2011 Apr; 17(7-8):1137-45.
  43. Bian, L., Stoker, A.M., Marberry, K.M, Ateshian, G.A., Cook, J.L., Hung, C.T. Effects of dexamethasone on the functional properties of cartilage explants during long term culture. Am J Sports Med. 2010 Jan; 38(1):78-85.
  44. Bian, L., Fong, J.V., Lima, E.G., Stoker, A.M., Ateshian, G.A., Cook, J.L., Hung, C.T. DDynamic mechanical loading enhances functional properties of tissue-engineered cartilage using mature canine chondrocytes. Tissue Engineering Part A. 2010 May;16(5):1781-90.
  45. Bian, L., Ng, K.W., Lima, E.G., Williams, D.Y., Ateshian, G.A., Hung, C.T. Influence of temporary chondroitinase ABC-induced GAG suppression on maturation of tissue engineered cartilage. Tissue Engineering Part A. 2009 Aug; 15(8):2065-72.
  46. Bian, L., Kaplun, M., Williams, D.Y., Ateshian, G.A., Hung, C.T. Influence of chondroitin sulfate on the biochemical, mechanical and frictional properties of cartilage explants in long term culture. Journal of Biomechanics 2009 Feb 9; 42(3):286-90. Epub 2008 Dec 30.
  47. Bian, L., Angione, S.L., Ng, K.W., Lima, E.G., Williams, D.Y., Mao D.Q., Ateshian, G.A., Hung, C.T. Influence of decreasing nutrient path length on the development of engineered cartilage. Osteoarthritis and Cartilage, 2009 May;17(5):677-85.
  48. Bian, L., Lima, E.G., Angione, S.L., Ng, K.W., Williams, D.Y., Xu, D., Stoker, A.M., Cook, J.L., Ateshian, G.A., Hung, C.T. Mechanical and biochemical characterization of cartilage explants in serum-free culture. Journal of Biomechanics, 2008, 41 (6): 1153-1159.

Coauthored journal publications:

  1. Lin, Z., et al.; Bian, L.; *Yeung, KWK. Precisely controlled delivery of magnesium ions thru sponge-like monodisperse PLGA/nano-MgO-alginate core-shell microsphere device to enable in-situ bone regeneration. Biomaterials. 2018 Aug;174:1-16.
  2. Gao, S.; et al.; Bian, L.; *Zhang, A. Direct optical micropatterning of poly (dimethylsiloxane) for microfluidic devices. Journal of Micromechanics and Microengineering. 2018, accepted.
  3. Lin, S.; et al.; Bian, L.; *Li, G. Synergistic effects on mesenchymal stem cell-based cartilage regeneration by chondrogenic preconditioning and mechanical stimulation. Stem Cell Res Ther. 2017 Oct 3;8(1):221.
  4. X. Yan; et al.; Bian, L.; Kostarelos; *L. Zhang, Multifunctional biohybrid magnetite microrobots for imaging-guided therapy, Science Robotics, Vol. 2, Issue 12, eaaq1155, 2017.
  5. Zhang, Y.; Et al.; Bian, L.; *Zhao, N. Liquid–solid dual-gate organic transistors with tunable threshold voltage for cell sensing. ACS Applied Materials & Interfaces, 2017, 9 (44), pp 38687?8694
  6. Yu, Y.; Nie, Y.; Feng, Q.;  Qu, J.; Wang, R.; Bian, L.; *Xia, J. Targeted Covalent Inhibition of Grb2–Sos1 Interaction through Proximity-Induced Conjugation in Breast Cancer Cells. Molecular Pharmaceutics, 2017, Jan.
  7. D.; Liu, W.; Feng, Q.; Dong, C.; Liu, Q.; Duan, L.; Huang, J.; Zhu, W.; Li, Z.; Xiong, J.; Liang, Y.; Chen, J.; Sun, R.; Bian, L.; *Wang, D.  Effect of inorganic/organic ratio and chemical coupling on the performance of porous silica/chitosan hybrid scaffolds. Wang, Materials Science and Engineering: C, 2017 Jan 1;70(Pt 2):969-975.
  8. Hong, Y.; Yao, Y.; Wong, S.; Bian, L.; *AFT Mak. Change in viability of C2C12 myoblasts under compression, shear and oxidative challenges. Journal of Biomechanics. 2016 Mar 18
  9. Yao, Y.; Xiao, Z.; Wong, S.; Hsu, Y.C.; Cheng, T.; Chang, C.C.; Bian, L.; *AFT Mak. The effects of oxidative stress on the compressive damage thresholds of C2C12 mouse myoblasts: implications for deep tissue injury. Annals of biomedical engineering, 43 (2), 287-296
  10. D.; Liu, W.; Feng, Q.; Dong, C.; Liu, Q.; Duan, L.; Huang, J.; Zhu, W.; Li, Z.; Xiong, J.; Liang, Y.; Chen, J.; Sun, R.; Bian, L.; *Wang, D. Magnetite nanostructured porous hollow helical microswimmers for targeted delivery.  Advanced Functional Materials, Vol. 25, 5333-5342, 2015.
  11. O’Connell, G.D.; Lima, E.G., Bian, L., Chahine, N.O., Albro, M.A.; Cook, J.L.; Ateshian, G.A., Hung, C.T. Toward engineering a biological joint replacement. 2012, J Knee Surg, 2012;00:1 V10
  12. Lima, E.G., Bian, L., Ng, K.W., Mauck, R.L., Byers, B.A., Tuan, R.S., Ateshian, G.A., Hung, C.T. The beneficial effect of delayed compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3. Osteoarthritis Cartilage, 2007, 15(9): 1025-1033. PMID: 17498976
  13. Lima, E.G., Tan, A.R., Tai, T., Bian, L., Stoker, A.M., Ateshian, G.A., Cook, J.L., Hung, C.T. Differences in interleukin-1 response between engineered and native cartilage.  Tissue Engineering Part A. 2008, 14(10): 1721-1730. PMID: 18611148
  14. Lima, E.G., Tan, A.R., Tai, T., Bian, L., Ateshian, G.A., Cook, J.L., Hung, C.T. Physiologic deformational loading does not counteract the catabolic effects of interleukin-1 in long-term culture of chondrocyte-seeded agarose constructs. Journal of Biomechanics 2008, 41(15): 3253-9. PMID: 18823628
  15. Ng, K.W., Lima, E.G., Bian, L., O’Conor, C., Jayabalan, P.S., Stoker, A.M., Kuroki, K., Cook, C., Ateshian, G.A., Cook, J.L., Hung, C.T. Passaged adult chondrocytes can form engineered cartilage with functional mechanical properties: A canine model. Tissue Engineering Part A. 2010 Mar;16(3):1041-51. PMID: 19845465

Patents

Book chapters






















+Kang, H.; +Zhang, K.; Jung, H.J.; Yang, B.; Chen, X.; Pan, Q.; Li, R.; Xu, X.; Li, G.; Dravid, V.; *Bian, L.In situ reversible heterodimeric nanoswitch controlled by metal ion-ligand coordination regulates the adhesion, release, and differentiation of stem cells. Advanced Materials, accepted.

Bian Lab Biomaterials & Stem Cell Tissue Engineering Laboratory
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The Chinese University of Hong Kong


香港中文大學

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